The Role:
Moderna is seeking a talented and motivated Principal Research Associate to join the Clinical Flow Cytometry group to serve as a technical expert for the generation of high parameter flow cytometry data under GCLP guidelines to support clinical programs across multiple therapeutic areas. This position reports to the Director of the Clinical Cytometry in Moderna’s Clinical Biomarker Labs. The Principal Research Associate will work with a team of scientists to return high quality data for clinical trials conducted by Moderna. This will include development of cell-based flow cytometry assays, performing fit-for-purpose validations, and executing clinical sample testing. You will be an integral part in applying high parameter flow and complex assays to generate key clinical data to drive clinical trial decisions.
Here’s What You’ll Do:
Execute clinical sample testing under GCLP guidelines
Conduct ex vivo stimulation for functional profiling of immune responses using intracellular cytokine staining on clinical trial PBMC samples
High parameter immunophenotyping on PBMCs and whole blood samples
PBMC isolation and cryopreservation from blood products
Strict adherence to protocols related to technical details and documentation to ensure assay rigor and repeatability
Document procedures using LabVantage LIMS
Deliver high quality data within defined timelines and aligned to current industry expectations
Play a prominent role in a team developing high parameter spectral flow cytometry assays and applying them to clinical trial samples to generate key data. Potential to become a co-lead to support clinical study data generation.
Adhere to established experimental workflows and documentation procedures while working to improve processes for accuracy and efficiency
Run experiments independently from sample prep to acquisition, and accurately analyze (FCS-Express version 7) and present data
Assist in report writing: SOPs, analytical study plans, analytical study reports
Work with study leads in assay development, validation studies, and to prepare for clinical sample analysis on Cytek Aurora cytometers
Identify inconsistencies and gaps and work to establish mitigation strategies to avoid downtime/data loss
Work with the team to identify, test feasibility, and implement emerging laboratory techniques
Maintain and support safe lab practices and environment
Educate, guide, and train junior personnel where appropriate
Here’s What You’ll Bring to the Table:
BA or MS in Immunology, Life Sciences, Biology, or related field; >5yrs lab experience
Minimum of 3 years of flow cytometry experience and clinical sample testing with CRO or BioPharma
Direct flow cytometry experience from sample processing and staining, through sample acquisition
Spectral flow cytometry understanding and hands on experience is desired
In depth experience on cytometers such as Cytek Aurora, BD Fortessa/Symphony, and similar is preferred
Experience with cell culture, ex vivo assays, and cell isolation from tissues
Experience in assessing cell-mediated immunity through flow cytometry: ex vivo stimulation of PBMC and intracellular cytokine staining for functional profiling is highly preferred
Knowledge of system software for data analysis: FCS Express, OMIQ, FlowJo
Possess good computational skills, experienced with Word, Excel, Power Point, and GraphPad Prism
Up to date on best practices in flow cytometry and application to clinical trials
Demonstrated level of independence
An effective communicator and collaborator in a project team with good written and presentation skills
Flexibility with changing priorities and urgent project requests
Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:
About Moderna
In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna’s capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.
Moderna’s mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit (url removed).
Moderna is a smoke-free, alcohol-free and drug-free work environment.
Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!
Moderna is proud to be an equal opportunity workplace and is an affirmative action employer.
Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.
Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We’re focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.
Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at (url removed). (EEO/AAP Employer)
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