The Hata Lab in the Massachusetts General Hospital Cancer Center is seeking a highly motivated individual with a strong scientific background for a full-time laboratory research technician position. Research within the Hata Lab focuses on discovering mechanisms of drug resistance in lung cancer patients treated with targeted therapies and developing new therapies to overcome them. We seek to answer pressing clinical questions through patient-centered biological exploration. Our approach prioritizes the use of novel tumor models generated directly from patient tumor specimens for deep mechanistic investigation, with the goal of rapidly translating our laboratory findings into clinical trials. More information about the Hata Lab can be found at: https://hatalab.mgh.harvard.edu.
The candidate will assist with basic and translational research projects under the supervision of a post-doctoral research fellow, as well as Dr. Hata (PI). This project aims to identify T cell immunity against ALK, a fusion oncogene driver in a portion of non-small cell lung cancer (NSCLC) and other cancers. ALK positive tumors inevitably develop resistance to current therapies yet ALK is not expressed in adults, so ALK specific T cell receptors could form the rational basis for a cellular treatment, orthogonal to small molecule inhibition. This role includes preparing and performing laboratory experiments, potentially assisting with in vivo animal experiments, collection and documentation of procedures and results, analyzing data, and assisting with manuscript preparation.
This position is ideal for a recent college graduate looking to expand their laboratory research skills in a translational research setting and while making contributions to the rapidly-evolving field of cancer immunotherapeutics. This opportunity is designed to provide an enhanced experience for prospective graduate (PhD) and medical (MD, MD/PhD) students and provides excellent opportunities for leadership and career development, as well as co-authorship on manuscripts. Previous experience in an immunology or cancer research lab, working with mammalian cell culture, or working with mice is not required, however undergraduate research experience in a biologically relevant field is strongly preferred.We are looking for an enthusiastic candidate who is highly motivated, detail-oriented, and works well both independently and on a team.
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The Research Technician should also possess:
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