The Research Specialist will perform work to support the laboratory’s in-vitro and in vivo non-human primate research endeavors of tolerance and nonhuman primate stem cell-derived beta cell studies with minimal supervision from the PI; And carries out supervision of research projects on behalf of the PI’s of the Islet Isolation Specialized Service Facility (ISSF) at MGH. This includes the design and execution of the experiments, collection of and accurate recording of procedures and results, and summarization of the findings for publication. In the meanwhile, the Research Specialist will provide operational support to the Director of ISSF at MGH, adhering to Standard Operating Procedures (SOPs) that apply to human islet and/or hepatocyte manufacture preparation, manufacturing, conducting QC assays and laboratory operation. They will provide technical expertise to activities that pertain to human, non-human primate, porcine, & rodent islet manufacturing processes, quality control assays, and participate in large animal studies including pre- and post-operative care and surgery.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
The Research Specialist will provide daily technical support for MGH Islet Isolation Specialized Service Facility (ISSF), and will perform the following tasks:
Human Islet and/or Hepatocyte Manufacturing Supporting Responsibilities:
(In conjunction with other team members or independently)
Human Islet/Cell Manufacturing Responsibilities:
(In conjunction with other team members or independently)
Quality Control Responsibilities:
Large Animal and Rodent Islet Isolation:
Data management Responsibilities:
Basic Science research:
EDUCATION:
MD or PhD (required).
EXPERIENCE:
Seven-plus years of related work experience is required. Previous cGMP practice experience and large animal surgical experience are highly desirable. Experience coordinating or overseeing the work of others is helpful.
SKILLS/ ABILITIES/ COMPETENCIES REQUIRED:
Technical skills include, but not limited to, small and large animal surgery, PCR, electrophoreses, ELISA, histology, histochemistry, tissue/cell culture, stem cell generation, gene engineering and flow cytometry. Independently modifies techniques, as necessary.
Other required abilities and competencies: 1) excellent verbal and written communication skills; 2) proficiency in Word, PowerPoint, Excel, and Internet searches; 3) self-motivated and able to work independently; 4) work carefully, safely and properly use protective equipment; 5) knowledgeable and compliant in all hospital, State and Federal regulatory requirements, including hospital policy and procedures (where applicable to the performance of the job), Joint Commission on Accreditation of Healthcare Organizations (JCAHO), and Health Insurance Portability and Accountability Act of 1996 (HIPAA).
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