Division of Pulmonary and Critical Care Medicine
Massachusetts General Hospital and Harvard Medical School
Postdoctoral position available to study mechanisms of lung fibrosis in the Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital and Harvard Medical School. The Knipe Lab is looking for a hard-working and enthusiastic post-doctoral candidate to work on an existing project investigating mechanisms of Rho kinase signaling in endothelial cells in the context of fibrosis in the lungs. We have recently published that both Rho kinase isoforms (ROCK1 and ROCK2) are important for pulmonary fibrosis, and now we are using transgenic mouse tools and in vitro culture systems to explore the endothelial-specific role of ROCK in the development of fibrosis.
We are seeking a highly motivated, independent, innovative, and organized individual with an interest in translational biomedicine for this Post-Doctoral Research Fellow position. The appropriate candidate will work in a highly collaborative research environment that aims to define the role of endothelial dysfunction and vascular permeability as regulated by Rho kinase signaling, in the development of fibrosis. The position will involve (but not be limited to) planning and conducting in vivo mouse modeling of pulmonary fibrosis, ex vivo and in vitro cell culture experiments, histology and microscopy including widefield and confocal imaging, molecular biology techniques to analyze RNA and protein expression in cells and tissues, and sequencing (both bulk and single cell opportunities).
The project is well-situated to generate high impact publications, presentations at conferences and prepare the post-doc for a long-term career in academia or industry. Applicants with prior post-doctoral experience are encouraged to apply.
All interested candidates are encouraged to submit their CV/resume accompanied by a cover letter describing prior research experience to Dr. Knipe ([email protected]).EDUCATION:
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