GlaxoSmithKline Looking for Senior Scientist – Biopharm Upstream Process Development Full Time

Biopharm Process Development is a highly experienced Chemistry, Manufacturing and Controls (CMC) organization accountable for delivering robust, cost effective and competitive products and manufacturing processes spanning the full life-cycle of asset development from discovery through commercialization. These activities are delivered through state-of-the art internal facilities as well as strategic external partners. Collectively, the team is accountable for CMC activities encompassing cell line development, cell culture / microbial fermentation, purification development, and drug product / device development. We also pioneer innovative technologies to improve robustness, reduce cost of goods, and improve the patient experience.

Within Biopharm Process Development, the Microbial and Cell Culture Development department is responsible for the development of cell culture processes for the manufacture of GSK’s Biopharm assets. The Department is also responsible for the scale-up and tech transfer of the processes to manufacturing facilities all over the world.

Our aim is to integrate innovative expression and process platforms, automation, and advanced data analytics into the upstream process development workflow. An opportunity has arisen for a process development scientist to advance our automation capabilities and handle large sets of complex data. They will have the opportunity to develop new methods and build capability in automated workflows and data handling.

In this role, you will be a member of a highly skilled team of scientists and engineers responsible for development and optimization of bioprocesses employing ambr (advanced microscale bioreactor) technology, integrated analytical instrumentation, and data management.

Key responsibilities include:

• Proficiency in ambr15, ambr250 Fed Batch and Perfusion operations including troubleshooting, software, hardware, and integrated analytical instruments
• Provide technical support and expertise for execution of fed-batch and perfusion-based cell culture processes on the ambr platforms
• Ensure ambr platforms are in good working order at all times. Manage run scheduling, consumables inventory, repairs/maintenance, and general laboratory upkeep and organization.
• Actively participate in expansion and enhancement of system capabilities
• Team-based and independent execution of ambr bioreactor studies for development and optimization of cell culture processes, evaluation for facility fit, and small-scale model qualification.
• Interact with colleagues in key partner groups: scientists/engineers involved in upstream process scale-up and tech transfer, downstream process development and analytical method development scientists, data scientists and statisticians.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• Bachelor’s or Master’s degree in Bioprocess/Biochemical/Chemical Engineering or related Biological Science with 1+ years industrial experience
• Experience with laboratory automation (liquid handlers)
• Knowledge in routine cell culture and aseptic technique
• Experience working in a biological laboratory and familiarity with general laboratory procedures.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Proficiency with operation and troubleshooting ambr15, ambr250 and/or ambr250-Perfusion platforms
• Vial thaw, shake flask, Large Scale processing (3L, 50L)
• Proficiency with Flex2 on/offline, CedexBioHT, ViCell XR/Blu, RapidPoint500, TOF-Mass Spec, Rebel, Norma, etc.
• Solid theoretical background in cell biology and physiology.
• Writing and reviewing technical documents with a basic understanding of regulatory requirements
• Programming experience (e.g. Python, Matlab, RapidComm, Smartline Data Cockpit, Visual Basic, etc)
• Statistical analysis
• Familiarity with Lab Modernization, Automation, Connected Instruments (windows hardware/OS/networking/cameras) and Process Analytical Technology
• Excellent interpersonal and communication skills
• Ability to adapt quickly to new scientific areas and work across teams.

Why GSK?

Uniting science, technology and talent to get ahead of disease together

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

*LI-GSK

#CMCDevelopmentGSK

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

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