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Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered.
At AskBio, we’ve built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease, and congestive heart failure. Our gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library.
We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, and Spain.
Our vision: Pioneering science to create transformative molecular medicines.
Our mission: Lead innovative science and drive clinical outcomes to transform people’s lives.
Advance innovative science by pushing boundaries.
Bring transformative therapeutics to patients in need.
Provide an environment for employees to reach their fullest potential.
Our values:
Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.
The Research Associate II, Pre-Clinical Manufacturing reporting to the Preclinical Vector Manufacturing Team Lead will support the manufacture of research and GLP grade recombinant Adeno-associated virus (rAAV) vectors as part of AskBio’s Vector Core. This individual will provide input and support the planning and execution of small and large-scale manufacturing campaigns, associated documentation, and evaluate and report the results to colleagues. The rAAV vectors manufactured will support capsid technology development, intellectual property portfolio, and progression of internal and external early-stage gene therapy programs. This opportunity will be based in our Research Triangle Park (RTP), North Carolina headquarters.
Responsibilities
- Responsible for rAAV vector manufacturing for research and GLP grade studies to support rAAV technology improvements and progression of early-stage gene therapy programs.
- Manufacture rAAV vectors by independently executing upstream and downstream process activities such as cell maintenance, production in shake flasks, WAVE bioreactors, and stir tank bioreactors, and purification by filtration and chromatography technologies.
- Evaluate and summarize manufacturing data and close out batch documentation. As needed, prepare and present updates to internal customers and teams.
- Support process investigations, improvements, and optimization activities, engaging with senior research associates and process development scientists, as needed, for successful resolution or implementation.
- Support process development activities, including technology transfer and training, from internal and external subject matter experts
- Support the preparation of manufacturing reports and make oral presentations to scientists and management
Required Education and Experience
- BS or MS degree in a biological or engineering discipline required (Biotechnology, Chemistry/Biochemistry, Chemical/Biochemical Engineering, or equivalent)
- 2 – 5 years of relevant experience in lab laboratory research, biologics manufacturing and a desire to continue in a laboratory-focused role. Experience in bioprocess development or manufacture, preferably in rAAV and/or recombinant protein/biomolecule bioprocess manufacturing.
- Experience in laboratory research or biologics manufacturing and a desire to continue in a laboratory-focused role.
- Ability to work both independently and collaboratively in a fast-paced, team-oriented laboratory environment.
- Strong organizational, analytical, and problem-solving skills
- Demonstrated ability to present ideas, information, and data effectively via one-on-one discussions, team meetings and collaborative interactions.
- Demonstrated ability to generate results and innovative solutions with minimum supervision.
- Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail) is required.
- Knowledge and experience with upstream or downstream process operations, such as cell culture, centrifugation, depth filtration, tangential-flow filtration, and/or chromatography is required.
Preferred Experience and Skills
- Ability to multi-task and prioritize workload according to group’s goals priorities.
- Have a service-oriented and quality mindset/attitude.
- Experience with rAAV manufacturing is a plus.
- Experience with cGMP and following good documentation practices is a plus.
- Understanding of design of experiments and familiarity with statistical software, such as JMP.
Asklepios BioPharmaceutical, Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job‐related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at (phone number removed) or sending us an email at (url removed) .
Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio, through any medium, will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio, no fee or payment of any kind will be paid to the agency.
Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered.
At AskBio, we’ve built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson’s disease, and congestive heart failure. Our gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library.
We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, and Spain.
