The Karmacharya lab in the Center for Genomic Medicine at Massachusetts General Hospital and the Harvard Chemical Biology program at Harvard University, is seeking a highly motivated post-doctoral fellow candidate. Our lab is interested in developing innovative stem cell-based models to interrogate the molecular and cellular underpinnings of neuropsychiatric disorders. The selected candidate will be appointed as a post-doctoral fellow at the Massachusetts General Hospital and a research fellow at Harvard Medical School.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
We are looking to recruit a highly motivated postdoctoral research fellow to join a multidisciplinary research group focused on studying synaptic plasticity in the context of the disease biology of neuropsychiatric disorders using human iPSC-derived neurons and brain organoids. The project will include mechanistic studies of synaptic plasticity with newly synthesized small molecules in human iPSC-derived cortical neurons and brain organoids from healthy individuals and patients. Techniques will include high-content microscopy, single cell transcriptomic experiments, proteomic experiments, and electrophysiological experiments with microelectrode arrays as well as CRISPR-mediated alterations to identify genes involved in modulating synaptic plasticity. This is a unique opportunity for working in a highly collaborative research environment at the interface of chemistry, biology, and therapeutic development. The work will involve close collaborations with the Chemical Biology Program at the Broad Institute. The fellow will have simultaneous academic appointments at Harvard Medical School and Massachusetts General Hospital.
The post-doctoral fellow will be situated at MGH under the guidance and mentorship of Rakesh Karmacharya, MD, PhD.
SKILLS & COMPETENCIES REQUIRED:
The ideal candidate should have received (or expect to receive soon) a Ph.D. in neurobiology, stem cell biology, cell biology, or related field required.
• Must have 1-2 years experience in working with stem cells and have demonstrated expertise in the use of fluorescence microscopy, flow cytometry, cellular imaging/microscopy, and molecular biology (RT-PCR, cloning, immunoprecipitation, western blotting).
• Additional expertise in the use of CRISPR, RNA interference and viral vectors preferred.
• Must possess excellent computer skills and be able to perform quantitative analysis of large data sets.
• Advanced statistics or programming skills a plus.
• Excellent critical thinking skills and attention to detail needed.
• Must be able to use sound judgment to effectively solve problems, work independently, and handle a variety of tasks.
• Requires effective oral and written communication skills along with meticulous laboratory technique and recording skills. EDUCATION:
Minimum Required: Doctoral Degree
Preferred: Doctoral Degree
EXPERIENCE:
Required: Recent PhD graduate
SUPERVISORY RESPONSIBILITY:
Not Applicable
FISCAL RESPONSIBILITY:
Not Applicable
WORKING CONDITIONS:
Laboratory
EEO Statement
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
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