About Alltrna
Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company’s platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more info, (url removed).
About The Role
Alltrna is seeking to hire a broadly experienced, pragmatic, and energetic VP / SVP to lead our Translational Sciences function and be part of our company’s Leadership Team. This role requires depth and creativity to pioneer a radical & novel therapeutic platform to revolutionize the way we treat genetic diseases, both rare and common. As a platform company, we’re simultaneously approaching many diseases and indication types to help us understand what’s achievable, what’s possible, and to rapidly convert our platforms therapeutic capabilities into practice.
Core Responsibilities
In this role, you will innovate the ways Alltrna will translate laboratory discoveries and emerging platform technology to human therapeutics. Core to your mission will be the design, development and implementation of modeling approaches across therapeutic areas to inform critical decisions. Translational Science will collaborate with all groups within Research and Development, Process Development, Computational Biology and Machine Learning teams to develop computational models to understand the disease and the impact of targeted biological pathways. You will be responsible for framing critical questions to establish the right model systems and analytical strategies that enable lead optimization, critical Go/No Go decisions, and advancement of therapeutics into patients. The Head of Translational Science will build and lead the in vitro and in vivo pharmacology and DMPK groups at Alltrna, directly manage a team of scientists, and drive cross functional work with colleagues throughout the company.
Your goal would be to drive scientific understanding in four areas to support our translational science efforts:
To achieve these goals, you will be required to develop and characterize a variety of models – including in vivo, in vitro, and ex vivo – to evaluate exploratory safety, therapeutic effect, PK/PD and immunological properties related to our platform and triangulate evidence to predict potential therapeutic capabilities in humans. You’ll work closely with immunologists and computational colleagues to design and execute in vivo studies in translational animal models, analyze and interpret diverse biological data sets related to PK/PD, and establish new biomarkers and their inference. As a senior leader, you will also be responsible for scientific and personnel development and aligning near-term priorities/deliverables with longer term milestones for our Translational Sciences team.
Our ideal candidate has experience in more than one of the following: rare diseases, immunology and/or oncology; as well as familiarity with statistical or machine learning methods to prosecute questions therein.
Qualifications and Skills
What We’ll Offer You
Our Core Values
WE GIVE IT OUR ALL, EVERYDAY, FOR PATIENTS EVERYWHERE. WE ARE ALLTRNA.
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